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KMID : 0811820140180010036
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Journal of Korean Society of Pediatric Nephrology
2014 Volume.18 No. 1 p.36 ~ p.41
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Urine endothelin-1 as a Biomarker for Urinary Tract Infections in Children
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Kee Hyung-Min
Lee Dae-Yong
Yun Ki-Wook
Lim In-Seok
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Abstract
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Purpose: Urinary tract infections (UTIs) are the most common source of bacterialinfections in infants and young children. Accurate diagnosis and treatment isimportant because of their association with renal scarring, which can lead tocomplications. Urine endothelin-1 (ET-1) is the major renal isoform producedand released by renal mesangial cells in response to glomerular injury. This studyaimed to investigate whether urinary levels of ET-1 can be used as a biomarkerfor UTI diagnosis.
Method: We conducted a prospective study using medical records of 70 patientsbelow the age of 18 years, who visited Chung-Ang University Hospital from July2012 to July 2013. We classified the patients into the UTI and control groupsbased on urine culture studies. The UTI group was further divided into upper andlower UTI groups using 99m-Technetium dimercaptosuccinic acid scintigraphy.
Urine ET-1 was measured using enzyme linked immunosorbent assay with 0.3mL urine.
Results: The UTI and control groups were comprised of 45 and 25 patients, respectively.
Mean urine ET-1 levels were significantly higher in the UTI groupthan in the control group (1.41±0.35 pg/mL vs. 0.33±0.07 pg/mL, P =0.04). Therewas no significance difference in the quantitative value between the upper andlower UTI groups (P =0.552). There was no correlation between urine ET-1 andserum C-reactive protein (Pearson correlation [R]=0.24), urine ET-1 and serumwhite blood cell count (R=0.19).
Conclusion: Our study suggests that urine ET-1 can be used for early diagnosisof UTI in children.
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KEYWORD
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Urinary Tract Infections, Endothelin-1, Biological Markers, Pediatrics
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